Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model

Maria E O'Hanlon,Clare Tweedy,Filippo Scialo,Rosemary Bass,Alberto Sanz,Tora K Smulders-Srinivasan

Neurobiology of Disease（2022）

引用 4|浏览11

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摘要

•Mitochondrial electron transport chain mutations interact with parkin PD phenotypes.•Specific fly mutations in complexes I, II, III, and IV enhance or suppress parkin.•A cyclope complex IV subunit mutation suppresses parkin early gross motor defects.•Specific ETC subunit roles could be vital in PD and should be investigated further.

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关键词

Mitochondria,electron transport chain,Oxidative phosphorylation,Parkin,PINK1,Cyclope,COX5A,Parkinson's disease,Drosophila melanogaster,Fruit flies

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