Iodine pentoxide-mediated oxidative selenation and seleno/thiocyanation of electron-rich arenes
Organic & Biomolecular Chemistry(2022)
摘要
A simple and efficient method for the regioselective selenation of electron-rich arenes by employing non-metal inorganic iodine pentoxide (I2O5) as a reaction promoter under ambient conditions has been developed. The present protocol showed broad functional group tolerance and easy-to-operate and time-economical features. Additionally, this protocol also allows access to 3-seleno and 3-thiocyanoindoles by the use of readily available selenocyanate and thiocyanate salts. A mechanistic study indicated that the transformation operated through selenenyl iodide-induced electrophilic substitution processes.
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关键词
oxidative selenation,iodine,seleno/thiocyanation,pentoxide-mediated,electron-rich
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