Photoacoustic Characterization of Bone Physico-Chemical Information
Biomedical Optics Express(2022)
摘要
Osteoporosis usually alters the chemical composition and physical microstructure of bone. Currently, most clinical techniques for bone assessment are focused on the either bone microstructure or bone mineral density (BMD). In this study, a novel multi-wavelength photoacoustic time-frequency spectral analysis (MWPA-TFSA) method was introduced based on the optical absorption spectra and photoacoustic effects of biological macromolecules, which evaluates changes in bone chemical composition and microstructure. The results demonstrated that osteoporotic bones had decreased BMD, more lipids, and wider trabecular separation filled with larger marrow clusters, which were consistent with multiple gold-standard results, suggesting that the MWPA-TFSA method has the potential to provide a thorough bone physico-chemical information evaluation noninvasively and nonradiatively.
更多查看译文
关键词
Photoacoustic Imaging,Tissue Optical Properties,Functional Imaging
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要