Challenges and limitation of MTAP immunohistochemistry in diagnosing desmoplastic mesothelioma/sarcomatoid pleural mesothelioma with desmoplastic features

Prakasit Sa-Ngiamwibool,Makoto Hamasaki,Yoshiaki Kinoshita,Shinji Matsumoto,Ayuko Sato,Tohru Tsujimura,Takahiko Kasai,Kenzo Hiroshima,Kei Kushitani,Yukio Takeshima,Kunimitsu Kawahara,Akinori Iwasaki,Kazuki Nabeshima

Annals of Diagnostic Pathology（2022）

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摘要

•A combination of MTAP and BAP1 IHC effectively distinguishes pleural mesothelioma (PM) from fibrous pleuritis (FP).•Desmoplastic PM/sarcomatoid PM with desmoplastic features (desmoPM) cases are encountered the unclear IHC assessment.•MTAP IHC is a useful marker in differentiating ordinary sarcomatoid PM from FP, but its effectiveness is limited in desmoPM.•CDKN2A FISH is the most effective diagnostic assays in discriminating desmoPM from FP

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关键词

Pleural mesothelioma,Desmoplastic mesothelioma,Sarcomatoid mesothelioma,BAP1,MTAP,CDKN2A FISH

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