Performance Evaluation of the AllCheck Hcg Card Point-of-Care Device and Method Comparison with the Alere Hcg Cassette Assay for Pregnancy Test

teum and fetal growth [1].It comprises an alpha (α) subunit that is noncovalently linked to a beta (β) subunit [2].The alpha subunit of hCG (hCGα) is identical to that of thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle stimulating hormone (FSH), while the beta subunit (hCGβ) is unique.Most urinary hCG is in the intact form in early pregnancy [3], and the core fragmented form of hCGβ becomes predominant by 10 weeks of pregnancy [4, 5].Serum and urine hCG detection has been widely used to diagnose pregnancy.In particular, point-of-care (POC) devices that apply immunochromatography to detect hCG in the urine are widely used in laboratories.However, the performance of these devices has not been fully evaluated.Understanding the limitation of urine hCG POC devices is important in the clinical setting because the exclusion of pregnancy is critical in patient manage-