Modulation of Radiation Biomarkers in a Randomized Phase II Study of 131I-MIBG With or Without Radiation Sensitizers for Relapsed or Refractory Neuroblastoma

Kevin Campbell,Susan Groshen,Angela C Evans,Stephen Wilson,Aimy Sebastian,Gabriela G Loots,Araz Marachelian,Myriam Armant,Sharmistha Pal,Daphne A Haas-Kogan,Julie R Park,Meaghan Granger,Katherine K Matthay,Matthew A Coleman,Steven G DuBois

Journal of Clinical Oncology（2023）

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摘要

Peripheral blood biomarkers relevant to radiation exposure demonstrate significant modulation after I-MIBG and concomitant radiation sensitizers affect extent of modulation. Biomarkers related to hematopoietic damage and apoptosis were associated with hematologic toxicity.

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关键词

neuroblastoma,MIBG,vorinostat,biomarkers

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