PROFILE OF COVID-19 PATIENTS WHO DEVELOPED ACUTE KIDNEY INJURY IN INTENSIVE CARE: MULTICENTRE STUDY

Abstract BACKGROUND AND AIMS The SARS-COV-2 acute respiratory distress fyndrome, which is the source of the infection known as coronavirus disease (COVID-19), spread rapidly, causing a pandemic that not only severely affected human health but also restricted the activities of daily living and weakens the global economy. Organs other than the lungs can be affected, including the kidneys. The incidence of acute kidney injury (AKI) in hospitalized patients with COVID-19 disease has been reported to range from 0.5% to 80%; thus, a better understanding of the pathophysiology of AKI during COVID-19 is crucial to manage and improve the survival of patients who develop an acute kidney injury (AKI) attributed to COVID-19 is a common complication of severe cases and is further associated with high mortality; and there is glomerular involvement associated with COVID-19, characterized in some cases by collapsing glomerulopathy or by tubular necrosis in other cases. The objectives of our study are to determine the incidence and describe the risk factors as well as the evolution of AKI in patients admitted for pulmonary infection with COVID-19 in intensive care unit. METHOD RESULTS Our study included 4261 patients hospitalized in intensive care in the different cities of Morocco; among them, 1495 (1/3) presented an AKI or 35.09%, the average age of our patients was 68.5 years or (25–99), with a male predominance or a sex ratio of 3 men to a woman. There is hypertension in 80% of cases, diabetes in 75% of cases, the association of hypertension and diabetes in 63% of cases, coronary heart disease in 10%, epilepsy in 1% and lymphoma in 0.5% of cases. CONCLUSION AKI is a complication that appears to be common in patients with severe SARS-CoV-2 infection, associated with a poor prognosis. Nephroprotection measures should be put in place to prevent the occurrence of AKI. Any patient hospitalized with SARS-CoV-2 should undergo an initial nephrologic evaluation, including proteinuria and urine sediment examination.