Mesenchymal Stem Cell-derived Extracellular Vesicle-enclosed microRNA-93 Prevents Hypoxic-ischemic Brain Damage in Rats

Xiaoding Shi,Xuelai Zhong,Lin Deng,Xiaohong Wu,Pinyi Zhang,Xin Zhang,Guonian Wang

Neuroscience（2022）

引用 6|浏览5

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摘要

•HDAC4 is highly expressed in brain tissues of MCAO adult rats.•HDAC4 suppresses Bcl-2 via deacetylation to promote OGD-induced neuron apoptosis.•miR-93 targets and inhibits HDAC4 in hippocampal neurons.•miR-93 from MSC-derived EVs represses OGD-treated neuron apoptosis via HDAC4/Bcl-2.•miR-93 from MSC-derived EVs protects adult rats against MCAO.

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关键词

middle cerebral artery occlusion,hypoxic-ischemic brain damage,microRNA-93,HDAC4,Bcl-2,hippocampal neurons

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