Pellino2 accelerate inflammation and pyroptosis via the ubiquitination and activation of NLRP3 inflammation in model of pediatric pneumonia

International Immunopharmacology（2022）

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摘要

•Pellino2 accelerated lung injury in mice of pediatric pneumonia.•Pellino2 accelerate inflammation and pyroptosis in model of pediatric pneumonia by NLRP3.•Pellino2 may serve as a potential approach for the treatment of pediatric pneumonia and other inflammatory diseases.

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关键词

Pellino2,Pediatric pneumonia,NLRP3,Ubiquitination

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