Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/KMT2A rearrangements.

Ka-Yuk Yuen,Yong Liu,Yong-Zhuo Zhou,Yin Wang,Dun-Hua Zhou,Jian-Pei Fang,Lu-Hong Xu

Cancer medicine（2023）

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摘要

Our findings show that pediatric patients with 11q23/KMT2A rearrangements have characteristic mutation patterns and varying clinical outcomes depending on different translocation partners, which could be utilized to develop more accurate risk stratification and tailored therapies.

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关键词

11q23/KMT2A,clinical outcome,gene mutations,pediatric acute myeloid leukemia,sequencing

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