THE CLINICAL OUTCOMES BETWEEN IVM AND CONVENTIONAL IVF FOR TREATMENT OF PCOS PATIENTS: A META-ANALYSIS

Introduction: Current studies on clinical outcomes of in vitro maturation (IVM) and in vitro fertilization (IVF) procedures for infertile polycystic ovary syndrome (PCOS) patients were inconsistent. Materials and methods: PubMed, the Cochrane Library, EMbase databases were searched of any design, published until July 25, 2018. In accordance with the Cochrane 5.1.0 standard, both a quality assessment and a risk assessment were conducted for including studies meeting the inclusion criteria. The extracted data were analyzed by Revman 5.3 and Stata 14.0 software. Results: Five studies were included the present meta-analysis. Compared to conventional IVF, IVM yielded significantly lower rate of oocyte cleavage (pooledRR=0.90, 95%CI 0.87 similar to 0.92), excellent-quality embryo (pooledRR=0.85, 95%CI 0.77 similar to 0.94), implantation (pooledRR=0.63, 95%CI 0.51 similar to 0.78), fertilization (pooledRR=0.95, 95%CI 0.93 similar to 0.98),moderate and severe OHSS (pooledRR=0.10, 95%CI 0.02 similar to 0.7) and Gn dose(pooledRR=-2.21, 95%CI-2.55 similar to-1.86).No significant differences in clinical pregnancy rate (pooledRR=0.88,95%CI 0.72 similar to 1.08), abortion rate (pooledRR=1.21, 95%CI 0.75 similar to 1.97), cycle cancellation rate (pooledRR=0.36, 95%CI 0.09 similar to 1.48)and birth rate (pooledRR= 1.12, 95%CI 0.85 similar to 1.47) were found between IVM with IVF. Conclusion: IVM was associated with a lower incidence of moderate and severe OHSS and a lower Gn dose. The implantation and pregnancy rates of IVM were significantly lower than standard IVF. Currently IVM was not an alternative to the standard IVF but may be a potential first line treatment option in some special situations. More intensive studies should be conducted to confirm results.