Twelve Salts Fabricated from 2-amino-5-methylthiazole and Carboxylic Acids through Combination of Classical H-bonds and Weak Noncovalent Associations

The 2-amino-5-methylthiazole was deployed in the construction of salts. By introducing it into the co crystallization system based on different carboxylic acids of mono-to dicarboxylic acids, a total of 12 novel salts were created. They have been featured by single crystal X-ray diffraction (SCXRD), infrared spectrum (IR) and elemental analysis (EA), their melting points (m.ps) were also surveyed. Their structural and supramolecular portions are fully examined. The outcome unveils that in all salts the aryl N in 2-amino-5-methylthiazole is the only protonated site. The crystal packing is woven by the strong N-H center dot center dot center dot N, N-H center dot center dot center dot O, O-center dot center dot H center dot center dot center dot N and O-H center dot center dot center dot O H-bonds. Deep analysis of the crystal packings told that a different bunch of additional C-H center dot center dot center dot C, CH3 center dot center dot center dot C, C-H center dot center dot center dot O/CH3 center dot center dot center dot O, C-H center dot center dot center dot S, CH3 center dot center dot center dot S, C-H center dot center dot center dot C-H, C-H center dot center dot center dot pi/CH2 center dot center dot center dot pi/CH3middotmiddotmiddot pi, N-H center dot center dot center dot pi, Cl center dot center dot center dot pi, O center dot center dot center dot C, O center dot center dot center dot S, O center dot center dot center dot pi, S center dot center dot center dot pi, C center dot center dot center dot S and pi center dot center dot center dot pi contacts contribute to the stabilization and expansion of the total structures. For the exquisite balance of the various non-covalent bonds these structures contained the homo/hetero supramolecular synthons or both, the common R 2 2 (8) graph set has been the widely encountered one. The present findings lay the basis for the burgeoning of new solid forms of 2-amino-5-methylthiazole, and furnish some new insights into its salts with carboxylic acids. (C) 2022 Elsevier B.V. All rights reserved.