Competitive Host-guest Electrochemical Detection of Ivermectin Drug Using a -Cyclodextrin/Graphene-based Electrode

The present study describes the novel development and application of an ivermectin (IVM) sensing electrochemical platform based on reduced graphene oxide (rGO) and the macrocyclic host beta-cyclodextrin (beta CD) molecule. The sensing method was based in the hostguest characteristics of beta-CD and competitive interaction between the target analyte and the methylene blue (MB) redox probe. Differential pulse voltammetry (DPV) was employed for the detection of IVM and a linear response between 0.5 and 40.0 mu molL(-1) with a limit of detection of 0.25 mu molL(-1) was obtained using the glassy carbon (GC)/ rGO/beta-CD electrode. The sensing platform was successfully applied for the detection of IVM in tap water samples, which may expand the applications of beta-CD towards the analysis of other chemical species.