Sec-O-glucosylhamaudol promotes the osteogenesis of pre-osteoblasts via BMP2 and Wnt3a signaling

Kyung-Ran Park,Hyun Hee Leem,Yoon-Ju Kwon,Il Keun Kwon,Jin Tae Hong,Hyung-Mun Yun

Journal of Functional Foods（2022）

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摘要

•SOGH was isolatedfrom the dried roots of Saposhnikoviadivaricata.•SOGH promotes osteoblast differentiation and mineralization.•SOGH promotes cell migration and adhesion.•The osteogenic properties of SOGH are mediated via the BMP2/Wnt3a signaling pathways.•SOGH has potential medicinal applications as a bone-protective compound.

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关键词

Wnt3a,SOGH,Saposhnikovia divaricata,Phytomedicine,Osteoblast,BMP2

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