Investigating Associations Between Urinary Phthalate Metabolite Concentrations and Chronic Diarrhea: Findings from the National Health and Nutrition Examination Survey, 2005–2010

This study aimed to explore the relationship between chronic diarrhea and urinary phthalate metabolite concentrations in US adults from the 2005-2010 NHANES study. After adjusting for potential confounding factors, logistic regression was used to explore the relationship between phthalates (PAEs) concentrations and chronic diarrhea, Bayesian kernel machine regression (BKMR), and quantile g calculation (quantile-based g calculation, qgcomp) which was used to study the combined and independent effects of PAEs on gastrointestinal infections. In the current study, 4260 adult participants over the age of 20 from the NHANES study were included, of whom 542 (12.72%) were assessed as having chronic diarrhea. In multivariate logistic regression analysis, after adjusting for all relevant covariates, the results showed that urinary phthalate metabolite concentrations were significantly associated with the risk of chronic diarrhea (P<0.001). Various PAEs were risk factors for chronic diarrhea, among which MiBP (OR=1.419, 95% CI: 1.416-1.423) and MCPP (OR=1.237, 95% CI: 1.235-1.239) were more significant. The BKME results showed a significant increase in the risk of chronic diarrhea with increasing total levels of the PAEs mixture. Mixed exposure to PAEs can promote the occurrence of chronic diarrhea, and the effect was more pronounced in obese people. Notably, most PAEs showed some degree of protection in overweight people. The risk effect of PAEs was more significant in the middle-aged and older population than in the younger population.