From Disorder to Normal Rhythm: Traveling-Wave Control of Cardiac Arrhythmias
Physical review applied(2022)
摘要
Lethal cardiac arrhythmias often involve the occurrence of spiral waves, whose control is essential for the treatment of the disease. While high-voltage shock-based control methods rely on ensuring an abrupt electrical synchronization of the heart, low-energy techniques mostly cause drift-induced termination of these waves. In particular, such a drift can be induced by a spatiotemporal modulation of domain excitability in optogenetically modified cardiac tissue. Here we demonstrate a low-energy optogenetics-based approach to suppress spiral waves via their transient chaotization and rapid drift.
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