Case Report: Immune Checkpoint Blockade Plus Interferon-Gamma Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis

Alexandra Serris,Amani Ouedrani,Fabrice Uhel,Marianne Gazzano, Vincent Bedarida,Claire Rouzaud,Marie-Elisabeth Bougnoux,Jean-Herle Raphalen,Sylvain Poiree,Olivier Lambotte,Guillaume Martin-Blondel,Fanny Lanternier

FRONTIERS IN IMMUNOLOGY（2022）

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摘要

Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment.

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关键词

invasive fungal disease, anti-PD 1, cerebral mucormycosis, covid-associated pulmonary aspergillosis, immunotherapy

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