PTSD is Associated with Increased Myo-Inositol in the Aging Brain: A Magnetic Resonance Spectroscopy Study

Danielle Sullivan,Erika Wolf,Sai Merugumala,Mark Logue,Dana Fein-Schaffer,Xiang Zhao,Hui Jun Liao,Catherine B. Fortier,Jennifer Fonda,William Milberg,Regina McGlinchey,Alexander P. Lin,Mark Miller

BIOLOGICAL PSYCHIATRY（2022）

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摘要

PTSD is a disabling condition associated with increased risk for early onset of age-related conditions such as Alzheimer’s disease (AD) and dementia. Evidence suggests that PTSD is associated with elevated systemic levels of oxidative stress and inflammation, which may contribute to the early onset of neurodegeneration. Advances in magnetic resonance spectroscopy (MRS) make it possible to measure neurometabolites of oxidative stress and inflammation in the brain.

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关键词

PTSD, MRS Imaging, APOE

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