Iridium-Catalyzed Borylation of 6‑Fluoroquinolines: Access to 6‑Fluoroquinolones
The Journal of Organic Chemistry(2022)
摘要
The Ir-catalyzed C–H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolonethe core structure of many antibiotics.
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关键词
iridium-catalyzed
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