MnFe2O4/MoS2 nanocomposite as Oxidase-like for electrochemical simultaneous detection of ascorbic acid, dopamine and uric acid

In this paper, we adopt a one-pot solvothermal synthesis method to prepare MnFe2O4/MoS2 nanocomposite (MMF) as an artificial enzyme for simultaneous electrochemical detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA) by screen-printed carbon electrode (SPCE). The exfoliated MoS2 surface contains numerous S defects and the spinel MnFe2O4 possesses non-homogeneous catalystic properties, high abundance of oxygen vacancies and surface. It provides high adsorption properties through the replacement of cations with large amounts of active clusters on the surface of nano-impurity composites, as well as the high surface activity of MoS2. Finally, we found that MMF can effectively and sensitively detect AA, DA and UA, and the peak current increases significantly in a certain scanning speed range. The electrochemical sensing performance of the synthetic nanocomposite for the analytes was better than that of individually synthesized MoS2 and MnFe2O4, respectively. The obtained limit of detection (LOD) of MMF for AA, DA and UA were 0.17 mM, 0.41 mu M and 0.14 mu M, respectively. In addition, the LOD for simultaneous detection of AA, DA and UA were as low as 0.90 mM, 0.16 mu M and 3.05 mu M, respectively. The prepared MMF showed good anti-interference ability and reproducibility for the analytes sensing.