Advances in enrichment methods for mass spectrometry-based proteomics analysis of post-translational modifications
Journal of Chromatography A(2022)
摘要
•post-translational modifications (PTMs) increase the functional diversity of the proteome.•mass spectrometry (MS)-based proteomics is the gold standard for PTM analysis.•unbiased MS identification and quantification of PTMs is challenging.•affinity and chemical enrichment methods have been developed to tackle this challenge.
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关键词
Post-translational modifications,Enrichment,Mass spectrometry,Immunoaffinity,Chemical enrichment strategies
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