Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia.

Maho Shinoda,Akiko Nishimura,Erika Sugiyama,Hitoshi Sato,Takehiko Iijima

Anesthesia progress（2022）

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摘要

We developed the PK/PD model for APAP administered intravenously. The analgesic effect can be expected ∼90 minutes after administration and to last >5 hours. It is suggested that APAP be administered ∼90 minutes prior to the onset of anticipated postoperative pain.

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关键词

Acetaminophen,Intravenous,Pharmacokinetic-pharmacodynamic model,Postoperative pain

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