Population pharmacokinetics of unbound ceftriaxone in a critically ill population

Department of Hospital Pharmacy, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands, partment 0.18 +/- 0.08 h-1. Dosing simulations predicted fT>4 mg /L of 88% (95% CI: 69 - 100%) for 2,000 mg ceftriaxone once daily and fT>4 mg /L of 100% (95% CI: 100 - 100%) both for 1,000 mg twice daily and continuous in-fusion of 2,000 mg daily. Conclusion: We de-veloped a reliable population PK model for unbound ceftriaxone in a critically ill popu-lation. Dosing simulations revealed fT>4 mg/L >= 60% for 1,000 mg twice daily and 2,000 mg once daily or by continuous infusion.