Targeting disrupted rich-club network organization with neuroplasticity-based computerized cognitive remediation in major depressive disorder patients

•This study confirmed the efficacy of neuroplasticity-based computerized cognitive remediation (nCCR) on executive function in patients with major depressive disorder (MDD).•The MDD patients in the nCCR group over 4 weeks showed increased the number of rich-club connections, global efficiency, and the SC-FC coupling strength compared to the control group.•Significant correlations between brain network topological parameters and TMT scores revealed increased executive function after cognitive training.