Autoinhibitory module underlies species difference in shear activation of von Willebrand factor

Nicholas A. Arce,Yi Liu,Wenchun Chen,X. Frank Zhang,Renhao Li

Journal of Thrombosis and Haemostasis（2022）

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摘要

Our results suggest that the regulation of VWF-GPIbα binding has been specifically tuned to work optimally in different rheological architectures. Differences in the AIM sequence may contribute to the difference in VWF shear response between human and mice.

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关键词

hemostasis,mechanosensation,platelets,single‐molecule force spectroscopy,von Willebrand factor

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