Longitudinal Immune Response to 3 Doses of Messenger RNA Vaccine Against Coronavirus Disease (COVID-19) in Pediatric Patients Receiving Chemotherapy for Cancer

Thomas Lehrnbecher,Ulrich Sack,Carsten Speckmann,Andreas H. Groll,Andreas Boldt,Benjamin Siebald,Simone Hettmer, Eva Maria Demmerath,Barbara Schenk,Sandra Ciesek,Jan Henning Klusmann,Christian Jassoy,Sebastian Hoehl

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

Our study in 21 pediatric cancer patients demonstrates that 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccine (BioNTech/Pfizer) elicited both humoral and cellular immunity in most patients during chemotherapy. Immunity was stronger in children with solid tumors and during maintenance therapy compared to those with hematological malignancies or during intensive chemotherapy.

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child,cancer,vaccination,SARS-CoV-2

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