Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression

Xu Zhou,Xiaoting Li,Kefan Yi,Chunhua Liang,Shanshan Geng,Jianyun Zhu,Chunfeng Xie,Caiyun Zhong

Bioorganic Chemistry（2022）

引用 5|浏览8

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摘要

•MgIG mitigated LPS-induced liver damage by inhibiting apoptosis and inflammation.•MgIG increased the expression of IL-22 in LPS-induced mice.•MgIG inhibited TLR4/NF-κB pathways and induced autophagy in LPS-treated mice.•MgIG has hepatoprotective effects partially by IL-22-activated autophagy.

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关键词

Magnesium isoglycyrrhizinate,IL-22,Oxidative stress,Autophagy

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