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Aims: The most demanding anastomosis of cephalic pancreaticoduodenectomy is pancreaticojejunostomy. In order to reduce the number of complications of pancreatico- jejunostomy, we worked to improve the technique of creating the anastomosis by modification of several aspects of the already standardized technique of creating a pancreaticojejunostomy. Materials and Methods: Observational cohort study was conducted on 50 patients who had undergone a cephalic pancreaticoduo-denectomy due to a periampullary carcinoma in the period from January 2011 to March 2016. We analyzed the effect of the presented technique on postoperative morbidity and mortality. Results: Of the 50 surgical patients, 31 (62%) were male. The mean age of the surgical patients was 58.8±10.08 years. Postoperative morbidity of 28% was lower than figures from literatures, which range from 35–43% (p > 0.05). Postoperative mortality was 6%, and in line with the figures from literature. Postoperative pancreatic fistula occurred in 6% of patients, which is also lower than 12.9% found in literature (p > 0.05). Conclusion: Postoperative morbidity in patients in whom a pancreaticojejunostomy was created with presented technique, including the incidence of a postoperative pancreatic fistula, was lower, although the difference was not statistically significant.