Non‐genetic and genetic predictors of haemodynamic instability induced by propofol and opioids: a retrospective clinical study

Qing‐ling Gu,Fa‐ling Xue,Zhuo‐ling Zheng,Hai‐ni Wang,Yan‐ping Guan,Yong‐zi Wen,Fang Ye,Min Huang,Wen‐qi Huang,Zhong‐xing Wang,Jia‐li Li

British Journal of Clinical Pharmacology（2022）

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摘要

We found that cardiovascular fundamentals and genetic variants of GABRB1, GABBR2, OPRM1, BDNF, CES2 and NR1I2 are associated with cardiovascular susceptibility, which can provide a reference for haemodynamic management in clinical anaesthesia.

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关键词

anaesthesia,cardiovascular susceptibility,haemodynamic instability,opioids,pharmacogenetics,propofol

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