Targeting PERK mediated endoplasmic reticulum stress attenuates neuroinflammation and alleviates lipopolysaccharide-induced depressive-like behavior in male mice

•LPS administration leads to enhanced expression of PERK in the hippocampus of mice.•ISRIB alleviates the depression-like behavior induced by LPS administration in mice.•ISRIB prevents the over-activation of microglia and resolves the neuroinflammation.