Tenofovir-Diphosphate in Dried Blood Spots vs Tenofovir in Urine/Plasma for Oral Preexposure Prophylaxis Adherence Monitoring.

Xin Niu,Rachel W Kubiak,Oraphan Siriprakaisil,Virat Klinbuyaem,Pra Ornsuda Sukrakanchana,Ratchada Cressey,Hideaki Okochi,Monica Gandhi,Tim R Cressey,Paul K Drain

Open Forum Infectious Diseases（2022）

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摘要

TFV-DP levels in DBS provide valuable insight into both dosing recency and cumulative doses from variable adherence patterns. Our observed benchmark TFV-DP concentrations were slightly higher than prior predicted estimates based on convenience samples.

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关键词

HIV,adherence,preexposure prophylaxis,tenofovir,tenofovir-diphosphate

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