Structural Connectivity Mediates the Relationship Between Blood Oxygenation and Cognitive Function in Sickle Cell Anemia.

Jonathan D. Clayden,Hanne Stotesbury,Jamie M. Kawadler,April Slee,Melanie Kolbel,Dawn E. Saunders,Anna M. Hood,Olu Wilkey,Mark Layton,Baba Inusa,Maria Pelidis,Subarna Chakravorty,David C. Rees,Jo Howard,Moji Awogbade,Christina Liossi,Fenella J. Kirkham,Chris A. Clark

Blood advances（2023）

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摘要

Key Points • Patients with sickle cell disease have weakened brain white matter connectivity compared with control subjects.• Weakened connectivity mediates the relationship between oxygen saturation and processing speed in patients.

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