Profiling of lipid mediators in atherosclerotic carotid plaques from type 2 diabetic and non-diabetic patients.

Louise Ménégaut,Aline Laubriet,Valentin Crespy,Maxime Nguyen,Jean-Michel Petit,Georges Tarris,Thomas Pilot,Alexis Varin,Hélène Choubley,Victoria Bergas,Jean-Paul Pais de Barros,Charles Thomas,Eric Steinmetz,David Masson

Prostaglandins, Leukotrienes and Essential Fatty Acids（2022）

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摘要

•Type 2 diabetics patients and non diabetic patients display a similar profile of lipid mediators in atherosclerotic carotid plaques.•Leukotriene B4 is detected at significant levels in carotid atheroma plaques and is highly correlated with 5-Hydroxyeicosatetraenoic acid concentrations.•Docosahexaenoic acid enrichment in carotid plaques correlates negatively with 5-Hydroxyeicosatetraenoic acid concentrations.

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关键词

Atherosclerosis,Leukotriene,Arachidonic acid,DHA,EPA,Resolvin,Diabetes

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