Hepatopancreatoduodenectomy for locally advanced perihilar cholangiocarcinoma: A case report and a plea not to underestimate surgical resectability

•Cholangiocarcinomas are characterized by low resectability most often due to late presentation•Longitudinally spreading cholangiocarcinoma can extend from the biliary plate to the intrapancreatic choleducus, being difficult to treat radically either with liver resection or pancreatoduodenectomy•Hepatoduodenopancreatectomy can treat locally advanced cholangiocarcinomas, but is characterized with a high rate of complications and few cases are performed in the Western world•Locally advanced cholangiocarcinomas should be evaluated in a high volume and skill HPB surgical centre•Clinical management must address potential complications (e.g. liver failure) in order to minimize failure to rescue from complications