BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.

Neuro-oncology（2023）

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摘要

Our data demonstrate that BCL-XL is critical for survival of senescent PA tumor cells and provides proof-of-principle for the use of clinically available BCL-XL-dependent senolytics.

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关键词

BCL-XL,BH3 mimetics,oncogene-induced senescence,pilocytic astrocytoma

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