Cytotoxic effects of Pd(II) complexes on cancer and normal cells: Their DNA & BSA adduct formation and theoretical approaches

Saikat Mandal,Swarup Kumar Tarai,Angana Pan,Rituparna Bhaduri,Pritam Biswas,Sankar Chandra Moi

Bioorganic Chemistry（2022）

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摘要

Pd(II) based less toxic and more effective alternative drug candidates of cisplatin & oxaliplatin. Cytotoxic property & molecular docking pose of the complexes with DNA & BSA support the anticancer drug activity and drug transportation through BSA.

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关键词

Pd(II) complex,DNA & BSA binding,ROS generation,Molecular docking

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