The clinical validation of a dried blood spot method for simultaneous measurement of cyclosporine A, tacrolimus, creatinine, and hematocrit

Marith I. Francke,Bart van Domburg, Samah Bouarfa,Daan van de Velde,Merel E. Hellemons,Olivier C. Manintveld, Suzanne Last-Koopmans,Midas B. Mulder,Dennis A. Hesselink,Brenda C.M. de Winter

Clinica Chimica Acta（2022）

引用 6|浏览5

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摘要

•A multicomponent dried blood spot method was clinically validated in transplant recipients.•A dried blood spot method was validated for cyclosporine A, tacrolimus, creatinine and hematocrit.•A correction for hematocrit is needed for clinical use of dried blood spot for cyclosporine A and tacrolimus.

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关键词

Creatinine,Dried blood spot,Hematocrit,Immunosuppression,Therapeutic drug monitoring,Transplantation

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