Synthesis and performance of temperature/pH dual stimulus responsive drug carriers based on core-shell structure

Magnetic mesoporous silicon was used as the core and P(MAA-co-NIPAM) polymer as the shell. Among them, MAA plays the role of pH response and NIPAM plays the role of temperature response. A core-shell stimulation responsive drug carrier Fe3O4/mSiO2/P(MAA-co-NIPAM) was constructed. The structure, magnetic properties, drug adsorption and drug release behavior of Fe3O4/mSiO2/P(MAA-co-NIPAM) nanoparticles were systematically studied. results show that Fe3O4/mSiO2/P(MAA-co-NIPAM) nanoparticles have obvious core-shell structure, and its saturation magnetization value was 9.77 emu/g. Dox was used as the drug model to investigate the drug loading and release ability of the samples. The results showed that the carrier had dual stimulation response to pH and temperature, and the release rate was higher at pH 6 and 40 ℃. The drug loading rate and entrapment efficiency were 11.43% and 76.21%, respectively. It has a potential application.