Imbalance in bone morphogenic proteins 2 and 7 is associated with hypertension and arterial stiffness in chronic kidney disease

Francisco J. Manzano-Lista,Marta Sanz-Gomez,Daniel Gonzalez-Moreno,Elena Vega-Martin,Marta Gil-Ortega,Isabel Aranguez,Angela Schulz,Miguel Angel Rubio,Gema Ruiz-Hurtado,Luis M. Ruilope,Reinhold Kreutz,Maria S. Fernandez-Alfonso

Journal of hypertension（2022）

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摘要

Our data show an imbalance in plasma, kidney and PVAT-derived BMP-2 and BMP-7 levels associated with hypertension and arterial stiffness. This might reflect a profibrotic/pro-calcifying propensity related with progressive CKD.

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关键词

bone morphogenic proteins,arterial stiffness,hypertension,kidney

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