Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome.

Journal of Crohn's & colitis（2023）

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摘要

These data demonstrate consistent epigenetic alterations at diagnosis in European patients with IBD, providing insights into the pathogenetic importance and translational potential of epigenetic mapping in complex disease.

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关键词

DNA methylation,Mendelian randomization,epigenetic clock,gene expression,genetics,inflammatory bowel diseases [IBD],methylation,prognosis,quantitative trait loci

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