Prevalence, Trends and Outcomes of Long-Term Inhaled Antibiotic Treatment in People with Cystic Fibrosis Without Chronic Pseudomonas Aeruginosa Infection – A European Cystic Fibrosis Patient Registry Data Analysis

•We searched the ECFS-PR for inhaled antibiotic use in pwCF without PA infection.•30% of pwCF not chronically PA infected were treated with inhaled antibiotics.•The major determinant of inhaled antibiotic use is past chronic infection with PA.•Over follow up, no benefit has been seen for treatment with inhaled antibiotics.•Randomized trials of inhaled antibiotics in pwCF without PA infection are needed.