Research progress and comparison of the establishment of animal models of radiotherapy or chemotherapy-induced oral mucositis

The mechanism of radiotherapy or chemotherapy-induced oral mucositis is not yet clear.And model establishment is needed in further study.In order to summarize the methods of model establishment and make a comparison,literature databases including Web of Science、Pubmed and CNKI were searched for related researches from January 2015 to January 2021. Hamsters, mice, rats,guinea pigs and miniature pigs were chosen to be modeling animals and modeling methods could be classified into: chemotherapy, chemotherapy combined with superficial mucosal irritation, radiotherapy, radiotherapy combined with superficial mucosal irritation and chemoradiotherapy. Advantages and disadvantages had been analyzed in this study to provide reference for following studies.