La complessità della diagnosi di una sindrome da reazione a farmaco nel bambino

DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a complex and potentially life-threatening drug induced hypersensitivity reaction. It is characterized by a massive skin reaction associated with multiorgan involvement, lymphadenopathy, eosinophilia. Here we describe a case of DRESS syndrome with acute liver failure in an 11-year-old boy triggered by Valproic Acid. We emphasize the importance of differential diagnosis on the basis of clinical, anamnestic and laboratory data.