A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression.

Hui Deng,Cindy Lin,Laura Garcia-Gerique,Shuyu Fu,Zachary Cruz,Erin E Bonner,Matthew Rosenwasser,Sridharan Rajagopal, M Naveen Sadhu,Chandru Gajendran, Mohd Zainuddin,Ramachandraiah Gosu, Dhanalakshmi Sivanandhan,Miriam A Shelef,Brian Nam,Dan T Vogl,Dmitry I Gabrilovich,Yulia Nefedova

Cancer research（2022）

引用 12|浏览19

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摘要

PAD4 regulates tumor progression by promoting neutrophil migration and can be targeted with a small molecule inhibitor to suppress tumor growth and metastasis and increase efficacy of immune checkpoint blockade therapy.

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关键词

neutrophil,tumor progression

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