CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway.

Junfu Fan,Gaozan Tong,Xixi Chen,Santie Li,Ying Yu, Shunan Zhu,Kunxuan Zhu,Zijing Hu,Yonggan Dong,Rui Chen,Junjie Zhu,Wenjie Gong,Zhicheng Hu,Bin Zhou,Yiming Chen,Litai Jin,Weitao Cong

British journal of pharmacology（2023）

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摘要

CK2 activation is critical to sustain the activated and fibrogenic phenotype of HSCs via SMO stabilization. Therefore, inactivation of CK2 by CX-4945 may be of therapeutic interest for liver fibrotic diseases.

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关键词

CK2,Hedgehog pathway,SMO,hepatic stellate cells,liver fibrosis

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