EP08.01-064 Serum NY-ESO-1 and XAGE1 Antibodies Predict and Monitor Clinical Responses to Immune Checkpoint Therapy for NSCLC
Journal of Thoracic Oncology(2022)
摘要
Immune checkpoint (IC) therapy is the mainstay in the treatment of non-small-cell lung cancer (NSCLC). IC therapy prolonged overall survival (OS) as compared with conventional chemotherapy; however, long-term survival benefits from IC therapy were moderate and limited. IC chemo-combinations highly cost and have high discontinuation rates due to adverse events. A long-term OS of IC monotherapy is very similar to those of IC chemo-combinations. Presently, tumor PD-L1 expression levels/tumor proportion score (TPS) are used as predictive biomarkers of response to IC monotherapy, though the clinical validation and performance are modest.
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关键词
immune checkpoint therapy,xage1 antibodies predict,ny-eso
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