Role of 3'-Deoxy-3'-[18F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase

Teresa A Szyszko,Joel T Dunn,Melissa M Phillips,John Bomalaski,Michael T Sheaff,Steve Ellis,Lucy Pike,Vicky Goh,Gary J R Cook,Peter W Szlosarek

JTO Clinical and Research Reports（2022）

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摘要

Early FLT imaging (PET2) agrees with EOT CT results in nearly two-thirds of patients. Both early and late FLT PET-CT provide evidence of response to ADIPemCis therapy in MPM and NSCLC. We provide first-in-human FLT PET-CT data in MPM, indicating it is comparable with modified RECIST.

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关键词

FLT PET-CT,Pegargiminase,Arginine,ASS1,Thoracic cancers

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