Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features.

Teijo Pellinen,Lassi Paavolainen,Alfonso Martín-Bernabé, Renata Papatella Araujo,Carina Strell,Artur Mezheyeuski,Max Backman,Linnea La Fleur,Oscar Brück,Jonas Sjölund,Erik Holmberg,Katja Välimäki,Hans Brunnström,Johan Botling,Pablo Moreno-Ruiz,Olli Kallioniemi,Patrick Micke,Arne Östman

Journal of the National Cancer Institute（2023）

引用 8|浏览23

暂无评分

摘要

Multimarker-defined CAF subsets were identified through high-content spatial profiling. The robust associations of CAFs with driver mutations, immune features, and outcome suggest CAFs as essential factors in NSCLC progression and warrant further studies to explore their potential as biomarkers or therapeutic targets. This study also highlights multiplex fluorescence immunohistochemistry-based CAF profiling as a powerful tool for the discovery of clinically relevant CAF subsets.

查看译文

关键词

fibroblast subsets,lung cancer,non-small

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要