P2X7 receptor activation impairs antitumour activity of natural killer cells.

Alberto Baroja-Mazo,Alejandro Peñín-Franch,Fernando Lucas-Ruiz,Carlos de Torre-Minguela,Cristina Alarcón-Vila,Trinidad Hernández-Caselles,Pablo Pelegrín

British journal of pharmacology（2023）

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摘要

Our results show that P2X7 activation represents a new mechanism whereby NK cells may lose antitumour effectiveness, opening the possibility of generating modified NK cells lacking P2X7 but with improved antitumour capacity.

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关键词

A438079,ATP,IL-2,P2X7,natural killer cells,tumour environment

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