Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca 2+ signaling pathway.

Jinmeng Liu,Fenghua Zhou,Yanchun Chen,Yingjun Guan,Fandi Meng,Zhenhan Zhao,Xuemei Wang,Xueshuai Gao,Xin Jiang,Haoyun Zhang,Qing Wang,Shuanhu Zhou,Xin Wang

American journal of translational research（2022）

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摘要

This study demonstrates that Wnt5a protects MNs in ALS by regulating cell viability, proliferation, apoptosis, and neurite growth through the Wnt/Ca signaling pathway. Our data indicate that the non-canonical Wnt/Ca signaling pathway regulated by Wnt5a is involved in MN degeneration in ALS.

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关键词

ALS,Wnt/Ca2+ signaling,Wnt5a,apoptosis,neurite growth,proliferation

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